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Recently, two mechanisms involved in the gut-brain axis have attracted increasing attention due to their role in the pathogenesis and progression of PD, namely, disruption of the composition of microorganisms living in the intestine (intestinal microbiome) and dysfunction of enteroendocrine cells, accompanied by impaired signaling through the GLP-1R [60]

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"Others find it quite profound, their favourite foods no longer spark joy, or they realise theyre no longer thinking about food all the time." Dr Alex Craven, a Melbourne-based upper gastrointestinal and bariatric surgeon, adds: "This isnt entirely new

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